Abstract
Recently, highly pathogenic avian influenza (HPAI) has spread globally, affecting various species. Despite strict biosecurity measures, outbreaks have been reported year-round across Europe, including Denmark. In March 2023, the EU introduced streamlined rules, which highlights the demand for research into HPAI vaccination strategies and surveillance.
In this study, we aim to explore the role of vaccination and its impact on disease control. We will evaluate various vaccination and surveillance strategies for managing poultry flock health. A key component will be to build a simulation model to assess the dynamics of vaccination as a protective measure in poultry flocks while accounting for factors like virus subtype, vaccine efficacy, housing conditions, and immunity duration to predict outcomes, including the number of infected animals, epidemic peaks, and mortality rates.
Furthermore, since vaccination can reduce clinical signs, mortality, and morbidity during outbreaks, we will also analyse the pros and cons of different vaccination strategies, such as the cost-effectiveness of integrating surveillance, highlighting the importance of a robust surveillance system to limit the spread of undetected outbreaks.
Data will be gathered from literature reviews, online sources, and experimental studies. Sensitivity analyses and collaborations with external partners will address potential delays or data scarcity. Preliminary results will be available for the conference to provide insights into the efficacy of vaccination and surveillance in controlling HPAI, ultimately aiming to enhance national risk models and vaccination strategies across Europe.
In this study, we aim to explore the role of vaccination and its impact on disease control. We will evaluate various vaccination and surveillance strategies for managing poultry flock health. A key component will be to build a simulation model to assess the dynamics of vaccination as a protective measure in poultry flocks while accounting for factors like virus subtype, vaccine efficacy, housing conditions, and immunity duration to predict outcomes, including the number of infected animals, epidemic peaks, and mortality rates.
Furthermore, since vaccination can reduce clinical signs, mortality, and morbidity during outbreaks, we will also analyse the pros and cons of different vaccination strategies, such as the cost-effectiveness of integrating surveillance, highlighting the importance of a robust surveillance system to limit the spread of undetected outbreaks.
Data will be gathered from literature reviews, online sources, and experimental studies. Sensitivity analyses and collaborations with external partners will address potential delays or data scarcity. Preliminary results will be available for the conference to provide insights into the efficacy of vaccination and surveillance in controlling HPAI, ultimately aiming to enhance national risk models and vaccination strategies across Europe.
Co-Author(s)
Sandra Filipa Oliveira Carapeto1, Anette Ella Boklund1, Lene Jung Kjær1, Yuan Liang1,2, Charlotte Kristiane Hjulsager2, Lars Erik Larsen1, Carsten Thure Kirkeby1
1Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark, 2Department of Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark
Abstract Category
Diagnostics, vaccination, or other mitigation strategies for poultry and wildlife