Abstract Title
Optimized competitive ELISA for the detection of H5 antibodies including new clades.
Abstract
Influenza viruses belong to the family Orthomyxoviridae. There are four types of influenza viruses: A, B, C and D; which are defined by the nature of their internal nucleocapsid antigen. Type A is the most conserved genus and can be further divided into subtypes based on their Hemagglutinin and Neuraminidase antigens. Some subtypes containing H5 or H7 are associated with highly pathogenic forms of the disease and high rate of morbidity and/or mortality. Since 2004, a new clade of H5 HPAI has been circulating worldwide in poultry flocks, leading to important losses. Recently, H5N1 infection in dairy cows has been identified in the United States, leading to different symptoms like milk production, reduced rumination or nasal discharge. Given the need for rapid and reliable serological tool, IDvet has developed a new H5 competitive ELISA able to detect anti-H5 antibodies including clades 2.2 and 2.3.4.4 in poultry and mammals. This document presents preliminary results obtained with this multi-species ELISA, ID Screen® Influenza H5 Antibody Competition 3.0 Multi-species (FLUACH5V3).
Co-Author(s)
Stephanie LESCEU1, Marina GAIMARD1, Chloe REDAL1, Jean-Emmanuel DRUS1, Catherine LEFEBVRE1, Marianne Zorbas1, Philippe POURQUIER1
1Innovative Diagnostics, Grabels, France
Abstract Category
Diagnostics, vaccination, or other mitigation strategies for poultry and wildlife